Negativation of Trypanosoma cruzi PCR within Six Months after Treatment of a Child with Nifurtimox
نویسندگان
چکیده
1 Service d’Accueil des Urgences Pédiatrique, Hôpital Robert-Debré-Assistance Publique-Hôpitaux de Paris, Paris, France, 2 Laboratoire de Parasitologie et de Mycologie, Hôpital Pitié-Salpêtrière-Assistance Publique-Hôpitaux de Paris, Paris, France, 3 Service des Maladies Infectieuses et Tropicales, Hôpital Tenon-Assistance Publique-Hôpitaux de Paris, Paris, France, 4 UMR216 “Mère et enfant face aux infections tropicales,” Institut de Recherche pour le Développement-Université Paris Descartes, Paris, France
منابع مشابه
Evaluation of nifurtimox treatment of chronic Chagas disease by means of several parasitological methods.
Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas disease from an area of endemicity in Chile who were treated according to current protocols. Under pre- and posttherapy conditions, blood (B) samples and xenodiagnosis (XD) sampl...
متن کاملDifferences in resistance to reinfection with low and high inocula of Trypanosoma cruzi in chagasic mice treated with nifurtimox and relation to immune response.
Reinfection of chronic chagasic mice after treatment with nifurtimox resulted in different outcomes according to the number of parasites used for inoculation. Nifurtimox-treated chagasic animals injected with 2,500 trypomastigotes developed higher parasitemia and increased mortality compared with nontreated chagasic mice. When reinfection was done with 25 trypomastigotes, treated and nontreated...
متن کاملFollow-up of an Asymptomatic Chagas Disease Population of Children after Treatment with Nifurtimox (Lampit) in a Sylvatic Endemic Transmission Area of Colombia
BACKGROUND Chagas disease is an anthropozoonosis caused by Trypanosoma cruzi. Two drugs are currently used for the etiological treatment of the disease: Nifurtimox (Lampit) and Benznidazole. This study presents a quasi-experimental trial (non-control group) of sixty-two patients who were treated for Chagas disease with Nifurtimox (Lampit), and were then followed for 30 months post-treatment. Th...
متن کاملEnantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.
With the aim of improving the available drugs for the treatment of Chagas disease, individual enantiomers of nifurtimox were characterized. The results indicate that the enantiomers are equivalent in their in vitro activity against a panel of Trypanosoma cruzi strains; in vivo efficacy in a murine model of Chagas disease; in vitro toxicity and absorption, distribution, metabolism, and excretion...
متن کاملParasitic Loads in Tissues of Mice Infected with Trypanosoma cruzi and Treated with AmBisome
BACKGROUND Chagas disease is one of the most important public health problems and a leading cause of cardiac failure in Latin America. The currently available drugs to treat T. cruzi infection (benznidazole and nifurtimox) are effective in humans when administered during months. AmBisome (liposomal amphotericin B), already shown efficient after administration for some days in human and experime...
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عنوان ژورنال:
دوره 9 شماره
صفحات -
تاریخ انتشار 2015